First known as the Buckeye & Great Western Business College, the school was founded in Sandusky in 1865 by Professor E. A. Hall. By 1867, the name was shortened to Buckeye Business College. The school was located at Union Hall, on the left side of Columbus Avenue, between Water and Market Streets.
The final home of the Sandusky Business College was the former Rush Sloane residence, located at 403 East Adams Street. The school was in operation there from 1923 until 1949, when the school closed due to declining enrollment. William O. Loudenslagel was the last owner of the Sandusky Business College.